|
Budgets:
|
1) Preclinical evaluation of new agents in tumour xenograft models |
|
Biobank Capitol Equipment List |
|
|
 |
Biobank Information Management System |
|
|
|
♦ With links to Misys, Cancer Registry, CoPath |
|
$300,000 |
|
High throughput digital scanner, TMA lab and IHC image analysis |
|
$300,000 |
|
♦ Plus extended warranty
♦ Plus image management/server |
|
$50,000
$80,000 |
|
Laser capture micro-dissection |
|
$300,000 |
|
♦ Plus extended warranty |
|
$50,000 |
|
Liquid nitrogen storage tank |
|
$50,000 |
|
Nanodrop / Agilent Bioanalyzer / Cytospin |
|
$52,000 |
|
Lab furniture |
|
$20,000 |
|
|
|
|
| SUBTOTAL |
|
$1,202,000 |
|
|
|
|
|
Personnel |
|
|
|
Research technician II $65,000 + 20% benefits (5 years)
|
$390,000 | |
|
♦ Processing of blood/fluids, tissue derivatives, QC |
|
|
|
Clinical trials nurse (or equivalent) $80,000 + 20% benefits (5 years) |
|
$480,000 |
|
♦ Consents, bloods, data |
|
|
|
|
|
|
| SUBTOTAL |
|
$870,000 |
|
|
|
|
| TOTAL |
|
|
$2,072.000 |
|
2) Testing Canadian Innovation |
|
N/A |
|
|
|
|
|
|
|
3) An Inpatient Drug Development Unit |
|
N/A |
|
|
|
|
|
|
|
4) Upgrading existent laboratory facilities in the Advanced Molecular Profiling Lab (AMPL) |
|
Estimate Costs (5 years) |
|
|
|
Space (1,200 sq ft) |
|
$750,000 |
|
Major Equipment (Sequencer and LTQ-Orbitrap protein mass spec.) |
|
|
|
Solexa Sequencer
Protein mass spectrometry: Orbitrap |
|
$1,250,000
$1,000,000 |
|
AMPL – X operating personnel costs |
|
|
|
Lung/Ovary/Pancreatic/Head and Neck
(10 FTE x 5 Years. Each technician $60,000 +20% benefits) |
|
$3,600,000 |
|
*Supplies (profiling gene expression, genomic abnormalities and protein analysis)
Lung/Ovary/Pancreatic/Head & Neck |
|
$8,000,000 |
|
**Supplies for germline and pharmacogenetic evaluations
500 Lung, 300 Ovarian, 300 Pancreatic, 500 Head & Neck |
|
$1,600,000 |
|
|
|
|
| TOTAL |
|
$16,200,000 |
|
|
|
|
|
*Supplies per sample: |
|
|
|
- Expression profiling (Affymetrix human exon array)
- miRNA profiling (Agilent)
- High density array CGH (Affymetrix 500K snp chip)
- Proteomic analysis (mass spec.)
- DNA/RNA isolation
- Animals (xenograft and drug testing)
- Other lab reagents, disposables, drugs, etc…
|
|
$850
$550
$500
$300
$100
$2,000
$500 |
| TOTAL |
|
$5,000 |
|
|
|
|
|
**Supplies for germline studies per sample: |
|
|
|
- 1 million SNP chip
- Others
|
|
$800
$200 |
| TOTAL |
|
$1,000 |
|
|
|
|
|
5) New Drug Development Training Program |
|
Salaries for trainees: |
|
|
|
Clinical Research Fellows (2 x $70,000 +20% Benefits)
Pharmacist (1 x 70,000 + 20% Benefits)
Graduate Students (2 x $25,000 + 20% Benefits) |
|
$168,000
$84,000
$60,000 |
|
|
|
|
| Total salaries: |
|
$312,000 |
|
|
|
|
|
Other expenses: |
|
|
|
(includes, pharmaceutical company employee drug development research and
training program, advertising and recruitment costs, contribution for travel to
one meeting per year, graduate registration fees, supplies, equipment and
incidentals) |
|
$88,000 |
|
|
|
|
| Total cost of program per year: |
|
$400,000 |
|
|
|
|
| Total cost of program over 5 years: |
|
$2,000,000 |
|
|
